Prevagen Reviews

by thememorypage

Prevagen (Apoaequorin) a Miracle Protein?

Prevprevagenagen promises clearer thinking, a sharper mind and the safeguarding of your memories — it even says so on the package.  The Prevagen website says:

 “Prevagen has been shown to improve memory and protect the brain by keeping brain cells alive longer.”

That sounds fantastic, and in an effort to know more, I notice an asterisk (*).  Scrolling down the webpage the asterisk informs me that…

 “these statements have not been evaluated by the Food and Drug administration and the product is not intended to diagnose, treat, cure or prevent any disease”

Confidence Inspiring Indeed…

So we known that the package says all our memory problems will be fixed, but the legal mumbo jumbo written by lawyers tells us otherwise.  Perhaps the lawyers really are telling us the truth.

No matter, lets dig into the ingredients and see what the real deal is.

Apoaequorin is the main active ingredient in the Prevagen — a supplement that is supposed to help with your brain power, memory recall and cognitive function.

What is Apoaequorin? 

In short it is a calcium binding protein.  Studies show that part of the reason for a decline in cognitive abilities (specifically as it relates to memory), is because as we age our ability to produce these calcium-binding proteins that promote brain power and cognitive function declines.

Calcium plays an important role in the ability of cells to talk to each other.  But like a finely tuned automobile, you need just the right about of oil for the car to run properly.  Too much oil, you spit out black smoke from your tail pipe.  Too little oil and your car engine seizes up.

In other words:  We get old and we stop making the stuff (calcium binding proteins) that we need to have a healthy functioning brain that runs like a finely tuned automobile.

How does Apoaequorin work?

Apoaequorin works as a neuroprotective calcium binding protein.   Basically Apoaequorin protects your neurons from excessive levels of calcium.

But here is the problem:

In order for a calcium binding protein like Apoaequorin to actually works properly, it must first get through the blood-brain-barrier.  In order to get through this barrier you must be smaller than 400 Daltons.

And what size do you think Apoaequin is? 22,000 + Daltons.

Sorry Apoaequorin, but you are too big for the blood-brain-barrier ride.

According to this study the way this supplement was tested was directly injecting it into the brains of lab rates.

They did not concern themselves with crossing the blood-brain-barrier and instead were just testing the effectiveness directly in the brain.

But even worse still is the fact that it is very unlikely the active ingredient in Prevagen would even survive the harsh environment of the human stomach.

Summary of Prevagen

This supplement has not been clearly tested in its current form and delivery method.  There is no evidence that the active ingredient (Apoaequorin) would survive the stomach or pass the blood brain barrier.

The placebo effect is very real and also very powerful.  Most users of Prevagen are most likely experiencing a placebo effect.   If you expect something to make you feel a certain way you probably will feel it.  Further, if you expect something to improve your memory, you might also try a little bit harder to remember things.

So basically, you probably shouldn’t buy this memory supplement.  It doesn’t appear to actually do anything.  As always, consult your doctor before taking any pills, starting any exercise program or changing your dietary habits.

{ 5 comments… read them below or add one }

Joseph Putnoki November 17, 2012 at 7:21 am

The article is valuable information and educational, provokes thinking too.
I wish the writer was not obscured “by thememorypage”. I think predatory and deceptive spruiking are out of control.

Credit to you who ever you are to help su push back.

Be well!



Cameron Wiley January 2, 2013 at 3:10 am

Prevagen is enticing and could be a gold mine for its developers. If it is legitimate it certainly would be investigated by other professionals. It would be important to see a minimum of one peer-reviewed paper reported in a recognized journal.


Mark Underwood January 14, 2013 at 3:06 pm

Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, July 1, 2011, Vol. 7, Issue 4, Supplement, Page e65

Mark Underwood, Peggy Sivesind, Taylor Gabourie, Quincy Bioscience,
Madison, Wisconsin, United States.
Background: Calcium is important for many neuronal processes and essential
for chemical signaling. As neurons age, their ability to regulate intracellular
calcium is diminished. Loss of calcium homeostasis is a significant
factor in age-associated neurodegeneration and the calcium hypothesis of
Alzheimer’s disease. Apoaequorin has previously demonstrated the ability
to reduce calcium related neuronal cell death in vitro. Qualitative in vivo
studies examining the effect of apoaequorin have shown improvements in
cognitive functioning and participant reported quality of life. Methods: A
double-blinded, placebo controlled study of apoaequorin in 222 healthy
adults with self-reported memory complaints. Applicants who met the inclusion
criteria and were not excluded by predetermined exclusion criteria were
given the AD8 Dementia Screening Interview (AD8) and randomized prior
to baseline testing. Over a three month study period, participants were tested
five times. The primary outcome measures were changes on specific assessments
of cognitive function. CogState Research (CogState Ltd.), a computerized
cognitive testing system, was used to quantitatively measure changes
in cognitive functioning. Statistical analysis was performed using IBM
SPSS Statistics version 19 (IBM, Inc.). Analyses were based on a Mixed-
Model-Repeated-Measures (MMRM) for changes between baseline (Day-
0) and conclusion (Day-90) of the study. Individuals who scored less than
two on the AD8 were segregated for analysis. Results: The apoaequorin
group showed improvements in verbal and visual learning, memory and delayed
recall that were not seen in the placebo group. After 90 days, the
apoaequorin group showed statistically significant improvement on the International
Shopping List (ISL) and the Groton Maze Learning Recall
(GMR) compared to placebo. The ISL showed a significant difference
between-arms from the baseline to Day-90 testing (F (1, 50) ¼ 4.33,
p <.05). Additionally, on the GMR, a significant difference between-arms
and a large effect size from the baseline to Day-90 testing (F (1, 50) ¼
4.93, p <.05, and Cohen’s d ¼ .76] was seen. Conclusions: These results
show a strong relationship between apoaequorin and improvements on several
quantitative measures of cognitive function. Results suggest an important
role and potential therapeutic utility for apoaequorin in delaying or
modifying the decline in cognitive functioning associated with aging.


jesseg January 21, 2013 at 7:17 pm

I’ve been taking prevagen for over a month and I haven’t noticed any results. I have lot of trouble with remembering, like where I place things and later forget where I left it. It took me next day to find my car keys, found them by accident. How long does it take for prevagen to take affect, if it’s really stands to its name.


Dan March 9, 2013 at 3:21 pm

I was going nuts with the typical memory problems reported by
my friends and relatives. Example . . . leave my desk with intentions
of retrieving my glasses left in another room and by the time I
had entered the room, I would find myself standing there trying
to recall why I was even there!! I found an ad for Prevagen and
decided to try it (even though I felt it was a bit expensive). I
had read the part that said you should continue to take the stuff
for at least 3 months. So I just kept taking it and sure enough
somewhere at about the 3 month period, I became aware that
I was not struggling nearly as much. I thought about the placebo
effect, but the difference in improvement, although gradual,
was just too significant to ignore. While I still will occasionally have a
memory relapse, I do believe in this stuff. My brother (a year younger
at age 68) reported the same effect at about the same time frame. I’d doubt that Prevagen works for everyone, that would be asking too much. But it has definitely helped improve my memory problems. My frustration level is definitely lot less!! One last comment, do not expect the change to be a
‘light switch’ type of notice. It’s more of a ‘one day you will begin to notice
the difference over a period of time’. I was CONSTANTLY forgetting
things, so it was fairly easy for me to notice when I began to hold
thoughts better when going from one place in my house to another.


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